Mathematical Simulation of Muscle Cross-Bridge Cycle and Force-Velocity Relationship
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چکیده
منابع مشابه
Mathematical simulation of muscle cross-bridge cycle and force-velocity relationship.
Muscle contraction underlies many essential functions such as breathing, heart beating, locomotion, regulation of blood pressure, and airway resistance. Active shortening of muscle is the result of cycling of myosin cross-bridges that leads to sliding of myosin filaments relative to actin filaments. In this study, we have developed a computer program that allows us to alter the rates of transit...
متن کاملEffects of cross-bridge compliance on the force-velocity relationship and muscle power output
Muscles produce force and power by utilizing chemical energy through ATP hydrolysis. During concentric contractions (shortening), muscles generate less force compared to isometric contractions, but consume greater amounts of energy as shortening velocity increases. Conversely, more force is generated and less energy is consumed during eccentric muscle contractions (lengthening). This relationsh...
متن کاملMuscle cross-bridge chemistry and force.
The recent article by Baker et al. (1999) presents a thermo-dynamic formalism that challenges the commonly held assumption that force production by muscle is localized to individual actin-bound myosin molecules. By assuming that the chemical reaction for the force-producing step is close enough to equilibrium to set ⌬G ϭ 0, the sum of the chemical and mechanical potentials of the products can b...
متن کاملThe cross-bridge cycle and skeletal muscle fatigue.
The functional correlates of fatigue observed in both animals and humans during exercise include a decline in peak force (P0), maximal velocity, and peak power. Establishing the extent to which these deleterious functional changes result from direct effects on the myofilaments is facilitated through understanding the molecular mechanisms of the cross-bridge cycle. With actin-myosin binding, the...
متن کاملCross-bridge properties derived from muscle isotonic velocity transients.
The rate constants for the turnover of cross-bridges during frog muscle contraction were determined from an analysis of the motion that follows step decreases in load. For a given projection from the myosin filament, there appears to be a range of about 100 A along the length of the filament over which the projection can attach to the actin filament and form a cross-bridge. The site of attachme...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2006
ISSN: 0006-3495
DOI: 10.1529/biophysj.106.092510